The eccentric and childish Pee-wee Herman embarks on a big adventure when his beloved bicycle is stolen. Armed with information from a fortune-teller and a relentless obsession with his prized possession, Pee-wee encounters a host of odd characters and bizarre situations as he treks across the country to recover his bike.
When Danny O'Shea's daughter is cut from the Peewee football team just for being a girl, he decides to form his own team, composed of other ragtag players who were also cut. Can his team really learn enough to beat the elite team, coached by his brother, a former pro player?